2022 Reviewers

We wish to thank 194 colleagues for their reviewing work, which was of tremendous help in contributing to the success of Isogloss in 2022. You can find the list of all Isogloss reviewers here

The achievements of Generative Syntax : a time chart and some reflections

In May 2015, a group of eminent linguists met in Athens to debate the road ahead for generative grammar. There was a lot of discussion, and the linguists expressed the intention to draw a list of achievements of generative grammar, for the benefit of other linguists and of the field in general. The list has been sketched, and it is rather interesting, as it presents a general picture of the results that is very 'past-heavy'. In this paper I reproduce the list and discuss the reasons why it looks the way it does.El maig de 2015, un grup d'eminents lingüistes es van reunir a Atenes per debatre el camí que cal seguir per a la gramàtica generativa. Hi va haver molta discussió i els lingüistes van manifestar la intenció de confeccionar una llista d'èxits de la gramàtica generativa en benefici d'altres lingüistes i de l'àmbit en general. La llista ha estat esbossada i és força interessant, ja que presenta una imatge general dels resultats molt "passada". En aquest treball reprodueixo la llista i comento els motius pels quals es veu d'aquesta manera

Doing Romance Linguistics in the 2020s

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Subject Clitics in Microcontact: A Case Study from Heritage Friulian in Argentina and Brazil

In this paper we present data from first generation immigrants (G1) and second and third generation heritage speakers of Friulian, a Rhaeto-Romance language spoken in North-Eastern Italy and also found in Argentina and Brazil. The target phenomenon is subject clitics (SCL s). We show that SCL s in heritage Friulian are in a process of being reanalyzed from being agreement markers to pronouns. While SCL s are obligatory in Friulian as spoken in Italy, they are often dropped in heritage Friulian in Argentina and Brazil; this phenomenon, we argue, needs to be interpreted as the drop of pronominal subjects, and not of agreement-like SCL s. We also demonstrate that the use of SCL s (reanalyzed as pronominal subjects) is conditioned both by grammatical factors (it happens more in some grammatical persons than in others) and by discourse factors (they are used more in the case of a continuation topic than in other topicalization contexts). This means that in heritage Friulian, discourse constraints on the expression of subjects are not being lost or weakened; in fact, against the general grammaticalization trend of pronominal forms, new discourse constraints are introduced

Field validation of a dusting cloth for mycological surveillance of surfaces

Efficient monitoring of surfaces for spores of filamentous fungi is essential for detecting minor contamination even when air samples test negative for fungi. This study evaluates and compares a pad prepared using a dusting cloth with Rodac contact plates and humidified swabs for detecting mycological contamination, and concludes that the new method is superior and cheaper

A new microfluidic platform for the highly reproducible preparation of non-viral gene delivery complexes

Transfection describes the delivery of exogenous nucleic acids (NAs) to cells utilizing non-viral means. In the last few decades, scientists have been doing their utmost to design ever more effective transfection reagents. These are eventually mixed with NAs to give rise to gene delivery complexes, which must undergo characterization, testing, and further refinement through the sequential reiteration of these steps. Unfortunately, although microfluidics offers distinct advantages over the canonical approaches to preparing particles, the systems available do not address the most frequent and practical quest for the simultaneous generation of multiple polymer-to-NA ratios (N/Ps). Herein, we developed a user-friendly microfluidic cartridge to repeatably prepare non-viral gene delivery particles and screen across a range of seven N/Ps at once or significant volumes of polyplexes at a given N/P. The microchip is equipped with a chaotic serial dilution generator for the automatic linear dilution of the polymer to the downstream area, which encompasses the NA divider to dispense equal amounts of DNA to the mixing area, enabling the formation of particles at seven N/Ps eventually collected in individual built-in tanks. This is the first example of a stand-alone microfluidic cartridge for the fast and repeatable preparation of non-viral gene delivery complexes at different N/Ps and their storage

Ensuring sample quality for biomarker discovery studies - Use of ict tools to trace biosample life-cycle

The growing demand of personalized medicine marked the transition from an empirical medicine to a molecular one, aimed at predicting safer and more effective medical treatment for every patient, while minimizing adverse effects. This passage has emphasized the importance of biomarker discovery studies, and has led sample availability to assume a crucial role in biomedical research. Accordingly, a great interest in Biological Bank science has grown concomitantly. In biobanks, biological material and its accompanying data are collected, handled and stored in accordance with standard operating procedures (SOPs) and existing legislation. Sample quality is ensured by adherence to SOPs and sample whole life-cycle can be recorded by innovative tracking systems employing information technology (IT) tools for monitoring storage conditions and characterization of vast amount of data. All the above will ensure proper sample exchangeability among research facilities and will represent the starting point of all future personalized medicine-based clinical trials

Loop electrosurgical excision procedure versus cryotherapy in the treatment of cervical intraepithelialneoplasia: A systematic review and meta-analysis of randomized controlled trials

AIM: Invasive cervical cancer is proceeded by a phase of preinvasive disease that is slow to progress and can be detected, treated, and collectively referred to as cervical intraepithelial neoplasia (CIN). Several excisional and ablative treatments for CIN have been studied, with loop electrosurgical excision procedure (LEEP) and cryotherapy being the two most commonly utilized. The objective of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to compare the compare harms and benefits of LEEP versus cryotherapy in women with CIN. METHODS: Electronic databases were searched from their inception until May 2018. We included all RCTs comparing cryotherapy versus LEEP in women with CIN. We included trials evaluating both HIV-seropositive and HIV-seronegative women. The primary outcome was the persistence of the disease at 6-month follow-up. Meta-analysis was performed using the random-effects model to produce summary treatment effects in terms of relative risk (RR) with 95% confidence interval (CI). RESULTS: Four trials, including 1035 women with CIN, were identified as relevant and included in the meta-analysis. Women who received LEEP for CIN had a significantly lower persistence at 6-month follow-up biopsy (RR: 0.87, 95% CI: 0.76-0.99) and significantly lower recurrence at 12-month follow-up biopsy (RR: 0.91, 95% CI: 0.84-0.99) compared to those who received cryotherapy. No between-group differences were found in the complications rate, but the analyses were not powered for these outcomes. CONCLUSIONS: In women with CIN, treatment with LEEP was associated with a significantly lower risk of persistence disease at 6 months and recurrence disease at 12 months compared to treatment with cryotherapy

A summertime investigation on urban PM fine and coarse fractions using hourly elemental concentration data series

The summertime composition of particulate matter in the atmosphere of some Italian towns (Florence, Genoa and Milan) has been studied by means of Ion Beam Analysis (IBA) techniques. The aerosol has been collected simultaneously by two-stage continuous streaker samplers, which separate and collect the PM10 particulate matter in two fractions. The hourly concentrations in air of about 20 elements have been extracted in the fine and coarse fractions of PM10 by Particle Induced X-ray (and Gamma-ray) Emission, PIXE (and PIGE) analysis. Absolute Principal Component Factor Analysis (APCFA) has been used to obtain the apportionment of the sources of particulate matter

Documenting Italo-Romance minority languages in the Americas: Problems and tentative solutions

This article describes the process of preparation and implementation of a data collection enterprise targeting Italo-Romance emigrant languages in North and South America. This data collection is part of the ERC Microcontact project, which aims to understand language change in contact by examining the language of Italian communities in the Americas